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David J Flavell Selected Research

Saporins

3/2021The Effect of Small Molecule Pharmacological Agents on the Triterpenoid Saponin Induced Endolysosomal Escape of Saporin and a Saporin-Based Immunotoxin in Target Human Lymphoma Cells.
11/2020The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin.
1/2019Augmentation of Saporin-Based Immunotoxins for Human Leukaemia and Lymphoma Cells by Triterpenoid Saponins: The Modifying Effects of Small Molecule Pharmacological Agents.
1/2018Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins.
5/2017Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells.
11/2016Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera.
2/2015Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.

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David J Flavell Research Topics

Disease

7Lymphoma (Lymphomas)
03/2021 - 07/2006
6Neoplasms (Cancer)
01/2022 - 02/2015
2Leukemia
03/2021 - 02/2015
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
02/2019
1B-Cell Lymphoma (Lymphoma, B Cell)
07/2006

Drug/Important Bio-Agent (IBA)

9Immunotoxins (Immunotoxin)IBA
01/2022 - 07/2006
7SaporinsIBA
03/2021 - 02/2015
4TriterpenesIBA
03/2021 - 02/2015
4SaponinsIBA
03/2021 - 02/2015
3AntigensIBA
07/2020 - 02/2015
3Proteins (Proteins, Gene)FDA Link
11/2016 - 07/2006
2LipidsIBA
11/2020 - 05/2017
2Immunoglobulin FragmentsIBA
01/2018 - 02/2015
2AntibodiesIBA
01/2018 - 02/2015
1Immunoconjugates (Immunoconjugate)IBA
07/2020
1Monoclonal AntibodiesIBA
07/2020
1Antineoplastic Agents (Antineoplastics)IBA
07/2020
1Poly I-CIBA
02/2019
1Ribosome Inactivating ProteinsIBA
01/2018
1CholesterolIBA
05/2017
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
11/2016
1Urokinase Plasminogen Activator ReceptorsIBA
11/2016
1Single-Chain AntibodiesIBA
02/2015
1Differentiation AntigensIBA
02/2015
1Rituximab (Mabthera)FDA Link
07/2006

Therapy/Procedure

2Therapeutics
02/2019 - 01/2018